StressCovidV1, Main, Exploration, bibRecord, 000720

COVID-19 Autopsies, Oklahoma, USA

Identifieur interne : 000720 ( Main/Exploration ); précédent : 000719; suivant : 000721

COVID-19 Autopsies, Oklahoma, USA

Auteurs : Lisa M. Barton [États-Unis] ; Eric J. Duval [États-Unis] ; Edana Stroberg [États-Unis] ; Subha Ghosh [États-Unis] ; Sanjay Mukhopadhyay [États-Unis]

Source :

American Journal of Clinical Pathology [ 0002-9173 ] ; 2020.

RBID : PMC:7184436

Abstract

AbstractObjectives

To report the methods and findings of two complete autopsies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individuals who died in Oklahoma (United States) in March 2020.

Methods

Complete postmortem examinations were performed according to standard procedures in a negative-pressure autopsy suite/isolation room using personal protective equipment, including N95 masks, eye protection, and gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcriptase polymerase chain reaction testing on postmortem swabs.

Results

A 77-year-old obese man with a history of hypertension, splenectomy, and 6 days of fever and chills died while being transported for medical care. He tested positive for SARS-CoV-2 on postmortem nasopharyngeal and lung parenchymal swabs. Autopsy revealed diffuse alveolar damage and chronic inflammation and edema in the bronchial mucosa. A 42-year-old obese man with a history of myotonic dystrophy developed abdominal pain followed by fever, shortness of breath, and cough. Postmortem nasopharyngeal swab was positive for SARS-CoV-2; lung parenchymal swabs were negative. Autopsy showed acute bronchopneumonia with evidence of aspiration. Neither autopsy revealed viral inclusions, mucus plugging in airways, eosinophils, or myocarditis.

Conclusions

SARS-CoV-2 testing can be performed at autopsy. Autopsy findings such as diffuse alveolar damage and airway inflammation reflect true virus-related pathology; other findings represent superimposed or unrelated processes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184436

DOI: 10.1093/ajcp/aqaa062
PubMed: 32275742
PubMed Central: 7184436

Affiliations:

Le document en format XML

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<author><name sortKey="Barton, Lisa M" sort="Barton, Lisa M" uniqKey="Barton L" first="Lisa M" last="Barton">Lisa M. Barton</name>
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<p>Complete postmortem examinations were performed according to standard procedures in a negative-pressure autopsy suite/isolation room using personal protective equipment, including N95 masks, eye protection, and gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcriptase polymerase chain reaction testing on postmortem swabs.</p>
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<p>A 77-year-old obese man with a history of hypertension, splenectomy, and 6 days of fever and chills died while being transported for medical care. He tested positive for SARS-CoV-2 on postmortem nasopharyngeal and lung parenchymal swabs. Autopsy revealed diffuse alveolar damage and chronic inflammation and edema in the bronchial mucosa. A 42-year-old obese man with a history of myotonic dystrophy developed abdominal pain followed by fever, shortness of breath, and cough. Postmortem nasopharyngeal swab was positive for SARS-CoV-2; lung parenchymal swabs were negative. Autopsy showed acute bronchopneumonia with evidence of aspiration. Neither autopsy revealed viral inclusions, mucus plugging in airways, eosinophils, or myocarditis.</p>
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Serveur d'exploration Stress et Covid

COVID-19 Autopsies, Oklahoma, USA

COVID-19 Autopsies, Oklahoma, USA

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